Nicotinic Acid → 2-cyclohexyl-2,3-dihydro-6-[4-(pyridine-3-carbonyl)piperazin-1-yl]-1H-isoindol-1-one

HRID 1370546Notes

Reaction equation

HRID 1370546 reaction equation
[CH:1]1([N:7]2[CH2:15][C:14]3[C:9](=[CH:10][C:11]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)=[CH:12][CH:13]=3)[C:8]2=[O:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:23](O)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[N:26][CH:25]=1>>[CH:1]1([N:7]2[CH2:15][C:14]3[C:9](=[CH:10][C:11]([N:16]4[CH2:17][CH2:18][N:19]([C:23]([C:24]5[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=5)=[O:30])[CH2:20][CH2:21]4)=[CH:12][CH:13]=3)[C:8]2=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 22180413HCID 22180413, compound

Product 1

HCID 120437232-cyclohexyl-2,3-dihydro-6-[4-(pyridine-3-carbonyl)piperazin-1-yl]-1H-isoindol-1-one

Procedure

In the same manner as in Example 35, the title compound was prepared from the compound obtained in step (e) of Example 1 and nicotinic acid.

Sources & evidence

ORD record
ord-772110b15f4b4d27bc7fca4c2ed6b254
Source dataset
uspto-grants-2003_06
Patent number
US06583144B2

Reaction notes

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