Bromocyclopentane → 2-Cyclopentyl-6-[4-(3,3-diphenyl-1-propyl)-piperazin-1-yl]-2,3-dihydro-1H-isoindol-1-one

HRID 1370558Notes

Reaction equation

HRID 1370558 reaction equation
[C:1]1([CH:7]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH2:20][NH:21][C:22]4=[O:25])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:32]1(Br)[CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH:32]1([N:21]2[CH2:20][C:19]3[C:23](=[CH:24][C:16]([N:13]4[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][CH:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[CH2:15][CH2:14]4)=[CH:17][CH:18]=3)[C:22]2=[O:25])[CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 8728BromocyclopentaneHCID 185109312,3-Dihydro-6-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-1H-isoindol-1-one

Product 1

HCID 185109022-Cyclopentyl-6-[4-(3,3-diphenyl-1-propyl)-piperazin-1-yl]-2,3-dihydro-1H-isoindol-1-oneYield 75.5%

Procedure

In the same manner as in Example 51, the title compound (44 mg) was prepared from the compound (50 mg) obtained in Example 50 and cyclopentyl bromide (27 mg).

Sources & evidence

ORD record
ord-b83706b243b947c89765493c42f01a85
Source dataset
uspto-grants-2003_06
Patent number
US06583144B2

Reaction notes

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