Allyl bromide → 2-Allyl-6-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-2,3-dihydro-1H-isoindol-1-one
Reaction equation
[C:1]1([CH:7]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH2:20][NH:21][C:22]4=[O:25])=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:32](Br)[CH:33]=[CH2:34]>>[CH2:34]([N:21]1[CH2:20][C:19]2[C:23](=[CH:24][C:16]([N:13]3[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][CH:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:15][CH2:14]3)=[CH:17][CH:18]=2)[C:22]1=[O:25])[CH:33]=[CH2:32]Participants
3
Procedure
In the same manner as in Example 51, the title compound (51 mg) was prepared from the compound (50 mg) obtained in Example 50 and allyl bromide (22 mg).
Sources & evidence
- ORD record
- ord-58c1fdc662cc425ca8ba22c1dd718616
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06583144B2
Reaction notes
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