HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-(bromomethyl)-3-nitro- → 6-[4-(3,3-Diphenyl-1-propyl)piperazin-1-yl]-2-(3-nitrobenzyl)-2,3-dihydro-1H-isoindol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-(bromomethyl)-3-nitro- | HCID 77568 | — |
| Reactant | 2,3-Dihydro-6-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-1H-isoindol-1-one | HCID 18510931 | — |
| Product | 6-[4-(3,3-Diphenyl-1-propyl)piperazin-1-yl]-2-(3-nitrobenzyl)-2,3-dihydro-1H-isoindol-1-one | HCID 18510784 | 57.2% |
Reaction Steps
In the same manner as in Example 51, the title compound (38 mg) was prepared from the compound (50 mg) obtained in Example 50 and 3-nitro benzyl bromide (39 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583144B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-2f11f30435664e2892da53aae6dedec1 |
| Source note | uspto-grants-2003_06 |