p-Toluenesulfonic acid → HCID 9887694, compound

Participants

Reaction Steps

A solution of 2-[4-(tert-butyl)phenyl]-4-oxo-4H-thieno[3,2-d] [1.3]oxazine (60 mg, 0.21 mmol) and p-anisidine (26 mg, 0.21 mmol) in toluene (1 mL) was treated with p-toluenesulfonic acid (4 mg) and the resulting mixture heated at relux for 30 h. The mixture was concentrated in vacuo and the residue was purified by flash chromatography (silica gel, hexanes/ethyl acetate) to yield 35 mg (41%) of the title compound.

Provenance & Evidence