4-Toluenesulfonyl chloride → 4,7-Bis(p-tolylsulphonyl)-1,4,7-triazacyclononane

関与物質

反応手順

N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane(1.1.20) was prepared by reacting(1.1.3) with two equivalents of p-toluenesulfonyl chloride. Two equivalents of N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane(1.1.20) hydrobromide were reacted with one equivalent of 1,3-diiodopropane in acetonitrile with excess potassium carbonate. 1,3-Bis[N,N′-bis(p-toluenesulfonyl)-1,4,7-triazacyclononane propane(1.1.21) was isolated and purified by chromatography. The p-toluenesulfonyl groups were removed using sulfuric acid and HBr to yield the title compound (1.1.19).

情報源と証拠