Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate → HCID 12071627, compound

HRID 1370709Notes

Reaction equation

HRID 1370709 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH:14]1([CH2:20][C@H:21]([N:25]2[C:29](=[O:30])[C@H:28]([CH2:31][CH:32]3[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]3)[NH:27][C:26]2=[O:38])[C:22](O)=[O:23])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH2:11]([O:10][C:8](=[O:9])[C:7]([C:5]1[N:6]=[C:2]([NH:1][C:22](=[O:23])[C@@H:21]([N:25]2[C:29](=[O:30])[C@H:28]([CH2:31][CH:32]3[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]3)[NH:27][C:26]2=[O:38])[CH2:20][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)[S:3][CH:4]=1)=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetateHCID 67483652HCID 67483652, compound

Product 1

HCID 12071627HCID 12071627, compound

Procedure

By using the conditions described in Step (iv) of Example 17, ethyl 2-amino-4-thiazoleglyoxylate was condensed with (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidinyl]propanoic acid [Example 17, Step (iii)] to give the title compound as a colorless foam: EI-HRMS m/e calcd. for C26H36N4O6S (M+) 533.2434, found 533.2431.

Sources & evidence

ORD record
ord-76920f683a524ab98a8c5e92c1b59fb0
Source dataset
uspto-grants-2003_06
Patent number
US06583288B2

Reaction notes

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