4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10279575, compound

HRID 1370710Notes

Reaction equation

HRID 1370710 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH:13]1([CH2:19][C@H:20]([N:24]2[C:28](=[O:29])[C@H:27]([CH2:30][CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[NH:26][C:25]2=[O:37])[C:21](O)=[O:22])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH2:11]([O:10][C:8](=[O:9])[CH2:7][C:5]1[N:6]=[C:2]([NH:1][C:21](=[O:22])[C@@H:20]([N:24]2[C:28](=[O:29])[C@H:27]([CH2:30][CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[NH:26][C:25]2=[O:37])[CH2:19][CH:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]2)[S:3][CH:4]=1)[CH3:12]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 67483652HCID 67483652, compound

Product 1

HCID 10279575HCID 10279575, compound

Procedure

By using the conditions described in Step (iv) of Example 17, ethyl 2-amino-4-thiazoleacetate was condensed with (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidinyl]propanoic acid [Example 17, Step (iii)] to give the title compound as a colorless foam: EI-HRMS m/e calcd. for C26H38N4O5S (M+) 519.2641, found 519.2620.

Sources & evidence

ORD record
ord-1367d836d5294f8abc89d22862c7b365
Source dataset
uspto-grants-2003_06
Patent number
US06583288B2

Reaction notes

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