1-(2-Methoxyphenyl)piperazine → HCID 9890461, compound

Participants

Reaction Steps

A suspension of 152 mg (0.5 mmol) of Compound 19, 144 mg (0.75 mmol) of 1-(2-methoxyphenyl)piperazine, 104 mg (0.75 mmol) of potassium carbonate and 150 mg (1 mmol) of sodium iodide in 20 ml of acetonitrile was refluxed for 17 hours. Post-treatment was conducted in a similar manner as in Example 18. The residue was purified by chromatography on a silica gel column (eluent: methanol/chloroform=1/19), whereby 160 mg of the title compound were obtained (yield: 99%).

Provenance & Evidence