Hydrochloric Acid → HCID 70015285, compound

Participants

Reaction Steps

A solution of the titled compound of Example 9d (3.27 g, 8.66 mmol) in glacial acetic acid (18.5 mL) was heated until all solids dissolved and then concentrated HCl (18.5 mL) was added. The solution was heated at reflux for 4 hours. The mixture was concentrated to an off white solid. The solid was treated with toluene, concentrated, and triturated with diethyl ether afforded the title amino acid as a white solid (3.04 g, 98%). Elemental Anal. Calcd. for C15H16NO5SCl: C, 50.35; H, 4.51; N, 3.91; S, 8.96. Found: C, 50.21; H, 4.43; N, 3.92; S, 9.04.

Provenance & Evidence