1,2-Dichloroethane → HCID 18512747, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the title compound of Example 11e (690 mg, 1.64 mmol) and O-tetrahydro-2H-pyran-2-yl-hydroxylamine (192 mg, 1.64 mmol) in anhydrous THF (40 mL), cooled to zero degrees C., was added EDC (330 mg, 1.72 mmol) and HOBT (264 mg, 1.72 mmol). After stirring at zero degrees C. for 5 hours and at room temperature for 18 hours, the solution was concentrated. The residue was dissolved into EtOAc (50 mL) and washed with 1M KHSO4 (2×50 mL), saturated NaHCO3 (2×50 mL), and brine (1×50 mL) and dried over Na2SO4. Purification by chromatography (1:1 EtOAc/hexane) yielded the title compound as a colorless oil (500 mg, 59%): Anal. Calcd. for C25H32N2O6S2: C, 57.67; H, 6.19; N, 5.38. Found: C, 57.48; H, 6.37; N, 5.11.

Provenance & Evidence