1,2-Dichloroethane → HCID 18512741, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the title compound of Example 11c (930 mg, 2.45 mmol) and O-tetrahydro-2H-pyran-2-yl-hydroxylamine (287 mg, 2.45 mmol) in anhydrous DMF (40 mL), cooled to zero degrees C., were added EDC (493 mg, 2.57 mmol) and HOBT (393 mg, 2.57 mmol). After stirring at zero degrees C. for 1 hour and at room temperature for 3 hours, the solution was partitioned between EtOAc and H2O. The resulting organic phase was washed with 1M KHSO4 (2×50 mL), saturated NaHCO3 (2×50 mL) and brine (1×50 mL), and dried over Na2SO4. Purification by chromatography (1:1 EtOAc/hexane) yielded the title compound as a colorless oil (400 mg, 34%).

Provenance & Evidence