Water → HCID 69541297, compound

Participants

Reaction Conditions

Reaction Steps

2,2-dimethylpropionic acid 5-bromo-2-hydroxyphenylester (500 mg) was dissolved in dimethylformamide and stirred with 1,8-diazabicyclo[5.4.0]undece-7-ene (DBU; 0.32 ml) for 10 minutes. Then, 2-bromopropane (0.25 ml) was added and heated at 40° C. After the reaction was completed, water was added to dilute and extracted with ethylacetate. An organic layer was dried over anhydrous magnesium sulfate, filtered, and distilled under reduced pressure. The residue was separated through a silica gel attributed chromatography (an eluting agent: ethylacetate/n-hexane=1/12, v/v). As a result, the present compound (340 mg, productive yield 60%) was obtained.

Provenance & Evidence