HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1370766Generated: November 1, 2026
Potassium Carbonate → 3-Butoxy-4-isopropoxy-4'-methanesulfonyl-biphenyl
https://huagongshe.com/reaction/1370766
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Isopropoxy-4'-methanesulfonyl-biphenyl-3-ol | HCID 18513228 | — |
| Reactant | Butane iodide | HCID 22226302 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 3-Butoxy-4-isopropoxy-4'-methanesulfonyl-biphenyl | HCID 10270037 | 88% |
Reaction Steps
4-isopropoxy-4′-methanesulfonyl-biphenyl-3-ol (30 mg) and potassium carbonate (20 mg) were dissolved in methylethylketone. Afterward, butane iodide (27 mg) and tetrabutylammoniumiodide (2-3 mg) was added one after another and heated for 24 hours at 40° C. After filtering just potassium carbonate, the residue was separated through a silica gel attributed chromatography (an eluting agent: ethylacetate/n-hexane=1/1, v/v). As a result, the present compound (30 mg, productive yield 88%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06583321B1 |
|---|
| Source dataset | uspto-grants-2003_06 |
|---|
| ORD ID | ord-cd60cb26378c4828af9bbbe964adc363 |
|---|
| Source note | uspto-grants-2003_06 |
|---|
