反应详情

34.5 g (0.15 mol) of the compound obtained in Step A are dissolved in 300 ml of methanol. 35 g (4 eq) of potassium hydroxide dissolved in 35 ml of water are added with vigorous stirring. After 3 hours at room temperature, the reaction mixture is hydrolysed over a mixture of ice/concentrated hydrochloric acid. The creamy white precipitate which forms is filtered off, washed several times with ice-cold water and dried over P2O5 using a dessicator. The title alcohol is recrystallised from a mixture of CH2Cl2/cyclohexane to yield white needles.

1. additionare added with vigorous stirring
2. additionthe reaction mixture is hydrolysed over a mixture of ice/concentrated hydrochloric acid
3. filtrationThe creamy white precipitate which forms is filtered off
4. washwashed several times with ice-cold water
5. dry with materialdried over P2O5 using a dessicator
6. customThe title alcohol is recrystallised from a mixture of CH2Cl2/cyclohexane
7. customto yield white needles