HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 70028981, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sulfoxonium, trimethyl-, iodide (1:1) | HCID 74498 | — |
| Reactant | HCID 69959769 | HCID 69959769 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 70028981 | HCID 70028981 | — |
Reaction Steps
5 g (23.9 mmol) of the compound obtained in Step A dissolved in 50 ml of DMSO are added dropwise to the ylid formed starting from 7.9 g (1.5 eq) of trimethylsulphoxonium iodide and 1.15 g (1.2 eq) of NaH (60% suspension in oil) in 20 ml of DMSO. The title compound is obtained in the form of an oil and is purified by chromatography over silica gel (eluant: CH2Cl2/i-PrOH 98/2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583319B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-66a28fee5c274339a198f2c3a83917a4 |
| Source note | uspto-grants-2003_06 |