2-Methyl-3-nitroaniline → HCID 4433548, compound

Participants

Reaction Steps

2-Methyl-3-nitroaniline (10.0 g, 65.7 mmoles, purchased from Aldrich) in pyridine (70 mL) was treated with methanesulfonyl chloride (5.09 mL, 65.7 mmoles) at 0° C. The reaction mixture was allowed warmed to room temperature and stirred for 2 hours. The reaction mixture was concentrated under reduced pressure and the crude products were diluted with diethyl ether (700 mL). The mixture was washed with 1N HCl (250 mL), water (250 mL) and brine (250 mL). The organic layer was dried (Na2SO4), filtered, and concentrated under reduced pressure to provide the title compound which was used in the next step without further purification.

Provenance & Evidence