2-Propanesulfonyl chloride → HCID 18512032, compound

HRID 1370780Notes

Reaction equation

HRID 1370780 reaction equation
[CH2:1]([N:8]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH2:15])[C:10]=1[CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24]([S:27](Cl)(=[O:29])=[O:28])([CH3:26])[CH3:25]>>[CH2:17]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:9]1[C:10]([CH3:16])=[C:11]([NH:15][S:27]([CH:24]([CH3:26])[CH3:25])(=[O:29])=[O:28])[CH:12]=[CH:13][CH:14]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 86586222HCID 86586222, compound

Product 1

HCID 18512032HCID 18512032, compound

Procedure

The product from Example 2B and isopropylsulfonylchloride were processed as described in Example 3 to provide the title compound. 1H NMR (500 MHz, DMSO-d6) δ1.23 (d, 6H, J=6.5 Hz), 2.39 (s, 3H), 3.18 (m, 1H), 4.04 (s, 4H), 6.91 (dd, 1H, J=7.5, 1.6 Hz), 6.97 (m, 2H), 7.19 (m, 2H), 7.26 (m, 8H), 8.86 (s, 1H); MS (APCI+) m/z 409 (M+H)+.

Sources & evidence

ORD record
ord-411c2315ce374a70b68c3916085c6a5d
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

Loading…