Dimethylsulphamoyl chloride → HCID 18511984, compound

HRID 1370781Notes

Reaction equation

[CH2:1]([N:8]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH2:15])[C:10]=1[CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][N:25]([CH3:30])[S:26](Cl)(=[O:28])=[O:27]>>[CH2:17]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:9]1[C:10]([CH3:16])=[C:11]([NH:15][S:26]([N:25]([CH3:30])[CH3:24])(=[O:28])=[O:27])[CH:12]=[CH:13][CH:14]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 86586222HCID 86586222, compound

Product 1

HCID 18511984HCID 18511984, compound

Procedure

The product from Example 2B and N,N-dimethylsulfamoylchloride were processed as described in Example 3 to provide the title compound. 1H NMR (500 MHz, DMSO-d6) δ2.25 (s, 3H), 2.33 (m, 6H), 3.88 (s, 4H), 6.72 (dd, 1H), J=7.7, 1.5 Hz), 6.82 (m, 2H), 7.03 (m, 2H), 7.10 (m, 8H), 8.73 (s, 1H); MS (APCI+) m/z 410 (M+H)+.

Sources & evidence

ORD record: ord-326c841c989a44b9ac456124b0f64e1f
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06583180B2

Reaction notes

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