4-Fluorobenzaldehyde → HCID 18512022, compound

HRID 1370788Notes

Reaction equation

[CH2:1]([NH:8][C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=1>>[CH2:1]([N:8]([CH2:26][C:25]1[CH:28]=[CH:29][C:22]([F:21])=[CH:23][CH:24]=1)[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 680234-Fluorobenzaldehyde

HCID 18512172HCID 18512172, compound

Product 1

HCID 18512022HCID 18512022, compound

Procedure

The product from Example 8A and 4-fluorobenzaldehyde were processed as described in Example 1C to provide the title compound. 1H NMR (300 MHz, CDCl3) δ7.07-7.32 (m, 9H), 7.00-6.85 (m, 3H), 6.10 (s, 1H), 4.03 (s, 2H), 4.02 (s, 2H), 2.95 (s, 3H), 2.33 (s, 3H); MS (ESI+) m/z 399 (M+H)+; Analysis calculated for C22H23FN2O2S 0.75 TFA: C, 58.26; H, 4.95; N, 5.79. Found: C, 58.26; H, 5.17; N, 5.63.

Sources & evidence

ORD record: ord-38ea0678dd8546698c110501b14dd36a
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06583180B2

Reaction notes

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