2,4-Difluorobenzaldehyde → HCID 18512170, compound

HRID 1370789Notes

Reaction equation

HRID 1370789 reaction equation
[CH2:1]([NH:8][C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:23]=1[CH:24]=O>>[CH2:1]([N:8]([CH2:24][C:23]1[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:22]=1[F:21])[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 737702,4-DifluorobenzaldehydeHCID 18512172HCID 18512172, compound

Product 1

HCID 18512170HCID 18512170, compound

Procedure

The product from Example 8A and 2,4-difluorobenzaldehyde were processed as described in Example 1C to provide the title compound. 1H NMR (300 MHz, CDCl3) δ7.40-7.18 (m, 6H), 7.11 (m, 2H), 6.92 (m, 1H), 6.72 (m, 2H), 6.07 (s, 1H), 4.07 (s, 4H), 2.93 (s, 3H), 2.30 (s, 3H); MS(ESI+) m/z 417 (M+H)+.

Sources & evidence

ORD record
ord-b11bec99b22f4aa98a1ba7bfd30a646e
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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