o-Fluorobenzaldehyde → HCID 18511977, compound

HRID 1370792Notes

Reaction equation

[CH2:1]([NH:8][C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH:24]=O>>[CH2:1]([N:8]([CH2:24][C:23]1[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=1[F:21])[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 67970o-Fluorobenzaldehyde

HCID 18512172HCID 18512172, compound

Product 1

HCID 18511977HCID 18511977, compound

Procedure

The product from Example 8A and 2-fluorobenzaldehyde were processed as described in Example 1C to provide the title compound. 1H NMR (300 MHz, CDCl3) δ7.22 (m, 8H), 7.10 (t, J=8.0 Hz, 1H), 6.98 (m, 3H), 6.11 (s, 1H), 4.13 (s, 2H), 4.10 (s, 2H), 2.91 (s, 3H), 2.31 (s, 3H); MS (ESI+) m/z 399 (M+H)+; Analysis calculated for C22H23FN2O2S 0.20 TFA: C, 63.96; H, 5.55; N, 6.65. Found: C, 64.11; H, 5.69; N, 6.61.

Sources & evidence

ORD record: ord-5cc87d7c3b3543f884502357fed708c8
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06583180B2

Reaction notes

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