HCID 18512252, compound → HCID 18511948, compound

Participants

Reaction Steps

The product from Example 6B (0.55 g, 1.4 mmoles) in THF (3.5 mL) was treated with diisobutylaluminum hydride (DIBAL) (2.94 mL, 2.94 mmoles, 1.0M in hexanes) dropwise at −78° C. After 30 minutes, an additional portion of DIBAL (1.5 mL) was added dropwise. After an additional 30 minutes, the acetone/dry ice bath was removed and the reaction mixture was carefully quenched with saturated NH4Cl. The mixture was diluted with diethyl ether (200 mL) and saturated sodium potassium tartrate (250 mL) and stirred vigorously for 2.5 hours. The two phases were separated and the organic phase was washed with brine, dried (Na2SO4), filtered, and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 4:1→1:1 hexanes:ethyl acetate) to provide the title compound as a yellow oil (0.46 g, 91%).

Provenance & Evidence