Sodium borohydride → HCID 18512008, compound

Participants

Reaction Steps

The product from Example 42A (0.017 g, 0.043 mmoles) in ethanol (2 mL) was treated with sodium borohydride (0.002 g, 0.053 mmoles). After stirring two hours at room temperature, the reaction mixture was quenched with saturated ammonium chloride and extracted with chloroform. The extracts were combined, dried with sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 30% ethyl acetate/hexanes) to provide the title compound (0.015 g, 88%). 1H NMR (300 MHz, CDCl3) δ7.63 (s, 1H), 7.12-7.38 (m, 13H), 4.67 (s, 2H), 4.06 (s, 4H), 2.85 (s, 3H); MS (ESI+) m/z 397 (M+H)+.

Provenance & Evidence