1-(Bromomethyl)-2,4-difluorobenzene → HCID 18512351, compound

HRID 1370821Notes

Reaction equation

HRID 1370821 reaction equation
[CH2:1]([O:4][C:5]1[CH:22]=[CH:21][C:8]([CH2:9][NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[C:12]=2[CH3:20])=[C:7]([F:23])[CH:6]=1)[CH:2]=[CH2:3].[F:24][C:25]1[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:26]=1[CH2:27]Br>>[CH2:1]([O:4][C:5]1[CH:22]=[CH:21][C:8]([CH2:9][N:10]([CH2:27][C:26]2[CH:29]=[CH:30][C:31]([F:33])=[CH:32][C:25]=2[F:24])[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[C:12]=2[CH3:20])=[C:7]([F:23])[CH:6]=1)[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 18511983HCID 18511983, compound

Product 1

HCID 18512351HCID 18512351, compound

Procedure

The product from Example 53C and 2,4-diflurobenzyl bromide were processed as described in Example 6B to provide the title compound. MS (ESI+) m/z 443 (M+H)+.

Sources & evidence

ORD record
ord-71b3541712a24df68ca8fd895f301162
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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