N-(3-{benzyl[4-(3-bromophenoxy)benzyl]amino}-2-methylphenyl)methanesulfonamide → HCID 18512310, compound

HRID 1370844Notes

Reaction equation

HRID 1370844 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31](Br)[CH:30]=2)=[CH:24][CH:23]=1)[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br-].[CH2:37]([O:39][C:40](=[O:44])[CH2:41][CH2:42][Zn+])[CH3:38]>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]2[CH:30]=[C:31]([CH2:42][CH2:41][C:40]([O:39][CH2:37][CH3:38])=[O:44])[CH:32]=[CH:33][CH:34]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18512042N-(3-{benzyl[4-(3-bromophenoxy)benzyl]amino}-2-methylphenyl)methanesulfonamideHCID 178471816HCID 178471816, compound

Product 1

HCID 18512310HCID 18512310, compound

Procedure

The product from Example 65D and 3-ethoxy-3-oxopropylzinc bromide (purchased from Aldrich) were processed as described in Example 49 to provide the title compound. MS (ESI+) m/z 573 (M+H)+.

Sources & evidence

ORD record
ord-dd9fbf3c3aee43beaaad6e76dbdff088
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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