Hydrazine hydrate (1:1) → HCID 18512083, compound

Participants

Reaction Steps

The product from Example 70B (0.323 g, 0.479 mmoles) in EtOH (5 mL) was treated with hydrazine hydrate (0.15 mL, 4.79 mmoles). The reaction was heated overnight at 60 C. Reaction mixture concentrated under reduced pressure, and residue dissolved in ethyl acetate. The mixture was washed with H2O (2×), brine, dried (Na2SO4), filtered, and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 10% to 20% MeOH:CHCl3) to provide the title compound (0.160 g, 61%). MS (ESI+) m/z 546 (M+H)+.

Provenance & Evidence