Morpholine → HCID 10189211, compound

HRID 1370856Notes

Reaction equation

HRID 1370856 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH2:36][CH2:37][CH2:38]Br)[CH:30]=2)=[CH:24][CH:23]=1)[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:40]1[CH2:45][CH2:44][O:43][CH2:42][CH2:41]1>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH2:36][CH2:37][CH2:38][N:40]3[CH2:45][CH2:44][O:43][CH2:42][CH2:41]3)[CH:30]=2)=[CH:24][CH:23]=1)[C:9]1[C:10]([CH3:20])=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 18512211HCID 18512211, compound

Product 1

HCID 10189211HCID 10189211, compound

Procedure

The product from Example 72D and morpholine were processed as described in Example 72E to provide the title compound. 1H NMR (300 MHz, CDCl3) δ7.10-7.30 (m, 11 H), 6.86 (d, 2 H), 6.63 (d, 1 H), 6.55 (m, 2 H), 6.33 (t, 1 H), 4.31 (s, 2 H), 4.28 (s, 2 H), 4.00 (m, 6 H), 3.65 (m, 2 H), 3.25 (m, 2 H), 2.95 (m, 2 H), 2.85 (s, 3 H), 2.25 (m, 2 H), 2.17 (s, 3 H); MS (ESI+) m/z 616 (M+H)+.

Sources & evidence

ORD record
ord-8ef6974297c34b3a81ccdc5edb6ff9ef
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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