HRID1370857

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccc(Oc2ccc(Br)cc2)cc1)Cc1ccc(F)cc1F

HCID18512210

未命名化合物

HCID178471550

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CCCc1ccc(Oc2ccc(CN(Cc3ccc(F)cc3F)c3cccc(NS(C)(=O)=O)c3C)cc2)cc1

HCID18512372

未命名化合物

PROCEDURE

实验过程

The product from Example 48B and 4-ethoxy-4-oxobutylzinc bromide (purchased from Aldrich) were processed as described in Example 49 to provide the title compound. MS (ESI+) m/z 623 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3643c3ac64f94d9b85daea241fa6540f
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06583180B2
来源说明: uspto-grants-2003_06

反应 SMILES

Br[C:2]1[CH:37]=[CH:36][C:5]([O:6][C:7]2[CH:35]=[CH:34][C:10]([CH2:11][N:12]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[F:33])[C:13]3[C:14]([CH3:24])=[C:15]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])[CH:16]=[CH:17][CH:18]=3)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Br-].[CH2:39]([O:41][C:42](=[O:47])[CH2:43][CH2:44][CH2:45][Zn+])[CH3:40]>>[F:33][C:27]1[CH:28]=[C:29]([F:32])[CH:30]=[CH:31][C:26]=1[CH2:25][N:12]([CH2:11][C:10]1[CH:9]=[CH:8][C:7]([O:6][C:5]2[CH:36]=[CH:37][C:2]([CH2:45][CH2:44][CH2:43][C:42]([O:41][CH2:39][CH3:40])=[O:47])=[CH:3][CH:4]=2)=[CH:35][CH:34]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][S:20]([CH3:23])(=[O:21])=[O:22])[C:14]=1[CH3:24]