Methanol → HCID 18511990, compound

Participants

Reaction Steps

The product from Example 76B (9.78 g, 24.1 mmoles) in MeOH (24 mL) was treated with concentrated H2SO4 (1 mL) and heated at reflux overnight. Reaction cooled and quenched with saturated NaHCO3. Reaction mixture diluted with ethyl acetate, washed with H2O, brine, dried (Na2SO4), filtered, and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography (silica gel, 20% ethyl acetate:hexanes) to provide the title compound. MS (ESI−) m/z 419 (M−H)−.

Provenance & Evidence