2-(Oxan-2-yloxy)ethan-1-ol → N-benzyl-N-(2-methyl-3-nitrophenyl)-N-(4-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenoxy}benzyl)amine

HRID 1370886Notes

Reaction equation

HRID 1370886 reaction equation
[CH2:1]([N:8]([CH2:19][C:20]1[CH:33]=[CH:32][C:23]([O:24][C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)=[CH:22][CH:21]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:10]=1[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH:35]1[O:40][CH2:41][CH2:42]O>>[CH2:1]([N:8]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:10]=1[CH3:18])[CH2:19][C:20]1[CH:33]=[CH:32][C:23]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH2:42][CH2:41][O:40][CH:35]3[CH2:36][CH2:37][CH2:38][CH2:39][O:34]3)[CH:26]=2)=[CH:22][CH:21]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 41668332-(Oxan-2-yloxy)ethan-1-olHCID 185122603-(4-{[Benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenol

Product 1

HCID 18512355N-benzyl-N-(2-methyl-3-nitrophenyl)-N-(4-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenoxy}benzyl)amine

Procedure

The product from Example 61F and 2-(tetrahydro-2H-pyran-2-yloxy)ethanol (purchased from Fluka) were processed as described in Example 62A to provide the title compound.

Sources & evidence

ORD record
ord-5f480eff37cd41558b7aec2eef671bd0
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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