alpha-Hydroxy-gamma-butyrolactone → 3-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]dihydrofuran-2(3H)-one

HRID 1370899Notes

Reaction equation

HRID 1370899 reaction equation
[CH2:1]([N:8]([CH2:19][C:20]1[CH:33]=[CH:32][C:23]([O:24][C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)=[CH:22][CH:21]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:10]=1[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O[CH:35]1[CH2:40][CH2:39][O:38][C:36]1=[O:37]>>[CH2:1]([N:8]([CH2:19][C:20]1[CH:33]=[CH:32][C:23]([O:24][C:25]2[CH:26]=[C:27]([CH:28]=[CH:29][CH:30]=2)[O:31][CH:35]2[CH2:40][CH2:39][O:38][C:36]2=[O:37])=[CH:22][CH:21]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[C:10]=1[CH3:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 545831alpha-Hydroxy-gamma-butyrolactoneHCID 185122603-(4-{[Benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenol

Product 1

HCID 185123983-[3-(4-{[benzyl(2-methyl-3-nitrophenyl)amino]methyl}phenoxy)phenoxy]dihydrofuran-2(3H)-one

Procedure

The product from Example 61F and α-hydroxy-γ-butyrolactone were processed as described in Example 62A to provide the title compound.

Sources & evidence

ORD record
ord-71a7b26be495419ab1841edcb86ea935
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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