Ethyl N-methylaminoacetate hydrochloride → HCID 18511912, compound

HRID 1370903Notes

Reaction equation

HRID 1370903 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:39]=[CH:38][C:25]([O:26][C:27]2[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][C:35](O)=[O:36])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C([O:43][C:44](=[O:48])[CH2:45][NH:46][CH3:47])C>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:26][C:27]2[CH:28]=[CH:29][C:30]([CH2:33][CH2:34][C:35]([N:46]([CH3:47])[CH2:45][C:44]([OH:43])=[O:48])=[O:36])=[CH:31][CH:32]=2)=[CH:38][CH:39]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:17])=[O:18])[C:10]=1[CH3:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 171173Ethyl N-methylaminoacetate hydrochlorideHCID 18511931HCID 18511931, compound

Product 1

HCID 18511912HCID 18511912, compound

Procedure

The product from Example 104A and sarcosine ethyl ester hydrochloride were processed as described in Example 104B to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ8.97 (s, 1 H), 7.15-7.38 (m, 8 H), 7.02 (m, 4 H), 6.87 (m, 4 H), 4.12 (s, 1 H), 4.06 (s, 2 H), 4.01 (s, 2 H), 3.99 (s, 1 H), 2.99 (s, 2 H), 2.91 (s, 3 H), 2.82 (s, 1 H), 2.76 (m, 2 H), 2.62 (m, 2 H), 2.39 (s, 3 H); MS (ESI) m/z 616 (M+H+).

Sources & evidence

ORD record
ord-8a8507434b43486391a8baaaa6ec6a44
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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