1-(Bromomethyl)-2,4-difluorobenzene → N-{4-[3-(allyloxy)phenoxy]benzyl}-N-(2,4-difluorobenzyl)-N-(2-methyl-3-nitrophenyl)amine
Reaction equation
[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH:27]=[CH:28][CH:29]=1)[O:8][C:9]1[CH:26]=[CH:25][C:12]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[C:16]=2[CH3:24])=[CH:11][CH:10]=1)[CH:2]=[CH2:3].[F:30][C:31]1[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:32]=1[CH2:33]Br>>[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH:27]=[CH:28][CH:29]=1)[O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][N:14]([CH2:33][C:32]2[CH:35]=[CH:36][C:37]([F:39])=[CH:38][C:31]=2[F:30])[C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[C:16]=2[CH3:24])=[CH:25][CH:26]=1)[CH:2]=[CH2:3]Participants
3
Procedure
The product from Example 61D and 2,4-difluorobenzyl bromide were processed as described in Example 6B to provide the title compound.
Sources & evidence
- ORD record
- ord-2f9554b4a339493589757c79e12d11be
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06583180B2
Reaction notes
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