HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 18512057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-(2,4-difluorobenzyl)-N-(4-hydroxybenzyl)-2-methyl-3-nitroaniline | HCID 18512160 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18512057 | HCID 18512057 | — |
Reaction Steps
The product from Example 33A(39 mg, 0.1 mmole) and di-t-butylazo dicarboxylate (35 mg, 0.15 mmole) in tetrahydrofuran (1.5 ml) were added to PPh3 on resin (70 mg, 0.3 mmole: loading 3 mmole/g) followed by ethanol (5.7 mg, 0.125 mmole) in 50 microliter tetrahydrofuran. Reaction mixture was shaken at room temperature overnight. Filtered off and solvent removed. Solaris 530 organic synthesis system from PE Biosystems was used to do this reaction. The residue purified by HPLC (CH3CN:0.1 TFA in H2O) on a YMC ODS guardpak column.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583180B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-95409d0f241747c9adac37d9b4ecc499 |
| Source note | uspto-grants-2003_06 |