1-(3-Aminopropyl)-2-pyrrolidinone → HCID 10233467, compound

HRID 1370912Notes

Reaction equation

HRID 1370912 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:39]=[CH:38][C:25]([O:26][C:27]2[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][C:35](O)=[O:36])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:40][CH2:41][CH2:42][CH2:43][N:44]1[CH2:48][CH2:47][CH2:46][C:45]1=[O:49]>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:26][C:27]2[CH:28]=[CH:29][C:30]([CH2:33][CH2:34][C:35]([NH:40][CH2:41][CH2:42][CH2:43][N:44]3[CH2:48][CH2:47][CH2:46][C:45]3=[O:49])=[O:36])=[CH:31][CH:32]=2)=[CH:38][CH:39]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:17])=[O:18])[C:10]=1[CH3:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 821111-(3-Aminopropyl)-2-pyrrolidinoneHCID 18511931HCID 18511931, compound

Product 1

HCID 10233467HCID 10233467, compound

Procedure

The product from Example 104A and 1-(3-aminopropyl)-2-pyrrolidinone were processed as described in Example 147 to provide the title compound. 1H NMR (500 MHz, CDCL3) δ7.26 (m, 2 H), 7.19 (m, 6 H), 7.11 (m, 3 H), 6.88 (m, 5 H), 6.79 (m, 1 H), 6.16 (s, 1 H), 4.04 (d, 4 H), 3.38 (t, 2 H), 3.22 (t, 2 H), 3.16 (dd, 2 H), 2.95 (m, 5 H), 2.51 (t, 2 H), 2.42 (t, 2 H), 2.33 (s, 3 H), 2.06 (m, 2 H), 1.62 (m, 2 H); MS (ESI+) m/z 669 (M+H)+.

Sources & evidence

ORD record
ord-1859ba02811f497db689d0cfcda3c7d5
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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