HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl L-prolinate hydrochloride → HCID 21130138, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl L-prolinate hydrochloride | HCID 2733200 | — |
| Reactant | 4-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)butanoic Acid | HCID 18512213 | — |
| Product | HCID 21130138 | HCID 21130138 | — |
Reaction Steps
The product from Example 100 (56 mg, 0.1 mmole) and L-Proline methyl ester hydrochloride (33 mg, 0.2 mmole) were processed as in Examples 213A and 224B to provide the title compound. 1H NMR (500 MHz, DMSO-d6) δ11.66-13.14 (br.s, 1 H), 8.95 (s, 1 H), 7.26 (m, 6 H), 7.18 (m, 3 H), 7.04 (m, 1 H), 6.96 (m, 2 H), 6.88 (m, 4 H), 4.22 (dd, 1 H), 4.03 (d, 4 H), 3.46 (m, 2 H), 2.91 (s, 3 H), 2.58 (t, 2 H), 2.39 (s, 3 H), 2.27 (t, 2 H), 1.97-2.24 (m, 2 H), 1.70-1.95 (m, 4 H); MS (APCI+) m/z 656 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583180B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-650b72d1305e4fda9841d245c90d266a |
| Source note | uspto-grants-2003_06 |