HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Aspartic acid, 1,4-dimethyl ester, hydrochloride (1:1) → HCID 68857544, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Aspartic acid, 1,4-dimethyl ester, hydrochloride (1:1) | HCID 2734892 | — |
| Reactant | 4-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenyl)butanoic Acid | HCID 18512213 | — |
| Product | HCID 68857544 | HCID 68857544 | — |
Reaction Steps
The product from Example 100 (56 mg, 0.1 mmole) and L-Aspartic acid dimethyl ester hydrochloride (40 mg, 0.2 mmole) were processed as in Examples 213A and 224B to provide the title compound. 1H NMR (500 MHz, DMSO-d6) δ11.46-13.35 (br.s, 2 H), 8.95 (s, 1 H), 8.13 (d, 1 H), 7.26 (m, 6 H), 7.18 (m, 3 H), 7.03 (m, 1 H), 6.96 (m, 2 H), 6.88 (m, 4 H), 4.54 (m, 1 H), 4.05 (s, 2 H), 4.01 (s, 2 H), 2.91 (s, 3 H), 2.69 (m, 1 H), 2.55 (m, 3 H), 2.39 (s, 3 H), 2.12 (t, 2 H), 1.76 (m, 2 H); MS (APCI+) m/z 674 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583180B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-8c669b497013493d9abe6a834789f437 |
| Source note | uspto-grants-2003_06 |