H-Ser(tBu)-OtBu HCl → HCID 68859989, compound

HRID 1370940Notes

Reaction equation

HRID 1370940 reaction equation
[CH2:1]([N:8]([CH2:21][C:22]1[CH:41]=[CH:40][C:25]([O:26][C:27]2[CH:39]=[CH:38][C:30]([O:31][CH2:32][CH2:33][CH2:34][C:35](O)=[O:36])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:10]=1[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[C:43]([O:47][C:48](=[O:57])[C@H:49]([CH2:51][O:52]C(C)(C)C)[NH2:50])([CH3:46])([CH3:45])[CH3:44]>>[CH2:1]([N:8]([CH2:21][C:22]1[CH:41]=[CH:40][C:25]([O:26][C:27]2[CH:39]=[CH:38][C:30]([O:31][CH2:32][CH2:33][CH2:34][C:35]([NH:50][C@H:49]([C:48]([O:47][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:57])[CH2:51][OH:52])=[O:36])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][S:16]([CH3:19])(=[O:17])=[O:18])[C:10]=1[CH3:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 16211506H-Ser(tBu)-OtBu HClHCID 18512383HCID 18512383, compound

Product 1

HCID 68859989HCID 68859989, compound

Procedure

The product from Example 233 and O-tert-butyl L-serine tert-butyl ester hydrochloride were processed as described in Example 251A to provide the titled compound.

Sources & evidence

ORD record
ord-a218cbcd66914ddca8710b9a4601ceb0
Source dataset
uspto-grants-2003_06
Patent number
US06583180B2

Reaction notes

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