tert-Butyl isoleucinate--hydrogen chloride (1/1) → HCID 68858862, compound

Participants

Reaction Steps

The product from Example 233 and L-isoleucine tert-butyl ester hydrochloride were processed as described in Example 251A and 258B to provide the titled compound. 1H NMR (500 MHz, DMSO-d6) δ12.06-12.82 (br.s, 1 H), 8.94 (s, 1 H), 7.99 (d, 1 H), 7.23 (m, 7 H), 6.87-7.09 (m, 7 H), 6.82 (d, 2 H), 4.19 (dd, 1 H), 4.04 (s, 2 H), 4.00 (s, 2 H), 3.93 (m, 2 H), 2.91 (s, 3 H), 2.38 (s, 3 H), 2.33 (m, 2 H), 1.92 (m, 2 H), 1.76 (m, 1 H), 1.40 (m, 1 H), 1.18 (m, 1 H), 0.83 (m, 6 H); MS (ESI+) m/z 688 (M+H)+.

Provenance & Evidence