Ethyl N-methylaminoacetate hydrochloride → N-[5-(4-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)pentanoyl]-N-methylglycine

Participants

Reaction Steps

The product from Example 234B and N-methylglycine ethyl ester hydrochloride were processed as described in Example 251A and B to provide the titled compound. 1H NMR (500 MHz, DMSO-d6) δ12.20-13.15 (br.s, 1 H), 8.94 (s, 1 H), 7.23 (m, 7 H), 7.03 (t, 1 H), 6.95 (m, 6 H), 6.82 (d, 2 H), 4.12 (s, 1 H), 4.04 (s, 2 H), 4.00 (s, 2 H), 3.94 (m, 3 H), 3.01 (s, 2 H), 2.91 (s, 3 H), 2.81 (s, 1 H), 2.40 (m, 4 H), 2.27 (t, 1 H), 1.58-1.79 (m, 4 H); MS (ESI+) m/z 660 (M+H)+.

Provenance & Evidence