Triphenylphosphine → HCID 68857864, compound

Participants

Reaction Steps

The product from Example 61F (88 mg, 0.2 mmole), (S)-5-(hydroxymethyl)-2-pyrrolidinone (58 mg, 0.5 mmole), di-tert-butyl azodicarboxylate (69 mg, 0.3 mmole), and triphenylphosphine (77 mg, 0.3 mmole) were dissolved in tetrahydrofuran (1.5 mL) in a capped test-tube and shaked at room temperature overnight. Ethyl acetate (2 mL) was added to dilute the reaction mixture. Then, the diluted organic solution was washed with water (2 mL) and saturated sodium chloride solution (2 mL), dried in vaccuo, and purified by HPLC to give the pure intermediate.

Provenance & Evidence