Homoserine lactone hydrobromide → 4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)-N-(2-oxotetrahydrofuran-3-yl)butanamide

Participants

Reaction Steps

The product from Example 116B (57 mg, 0.10 mmole) and (α-Amino-γ-butyrolactone hydrobromide (36 mg, 0.20 mmole) were processed as in Example 279A to provide the titled compound. 1H NMR (500 M/z, DMSO-d6) δ8.95 (s, 1 H), 8.36 (d, 1 H), 7.23 (m, 8 H), 7.04 (m, 1 H), 6.94 (m, 4 H), 6.69 (dd, 1 H), 6.50 (m, 2 H), 4.53 (d, 1 H), 4.33 (d, 1 H), 4.19 (ddd, 1 H), 4.06 (s, 2 H), 4.03 (s, 2 H), 3.94 (t, 2 H), 2.91 (s, 3 H), 2.40 (s, 3 H), 2.35 (m, 1 H), 2.27 (m, 2 H), 2.13 (m, 1 H), 1.91 (m, 2 H); MS (APCI+) m/z 702.9 (M+H)+.

Provenance & Evidence