Allyl Alcohol → HCID 18510217, compound

Participants

Reaction Steps

To a solution of diethyl difluoro(4-iodophenyl)methylphosphonate T. R. Burke Tetrahedron Letters, 551,1994, (2.50 g, 6.91 mmol) in DMF (25 ml) was added allyl alcohol (1.3 ml), silver acetate (1.1 g), palladium acetate (0.075 g), and triphenyl phosphine (0.175 g). The reaction mixture was refluxed for 2 hours. After cooling to room temperature the reaction was diluted with water and extracted with ethyl acetate. The mixture was filtered through a pad of celite. The organic layer was separated and washed with water, dried over magnesium sulfate, filtered and evaporated. The residue was purified using flash chromatography with hexane/ethyl acetate 75% to give 0.6 g of the title compound.

Provenance & Evidence