Triethylamine → HCID 18510240, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Trimethyl orthoformate	HCID 9005	—
Reactant	Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-	HCID 18462	—
Reactant	HCID 13397273	HCID 13397273	—
Solvent	Methanol	HCID 887	—
Product	HCID 18510240	HCID 18510240	—

Reaction Steps

To a solution of methyl 4(2-oxo-2-phenylethyl)benzoate (1 g, 3.9 mmole) in MeOH (40 mL) was added trimethylorthoformate 10 mL and CSA (50 mg). The reaction mixture was refluxed for 6 h. The mixture was cooled, then Et3N (0.5 mL) was added, and the mixture concentrated. The residue was dissolved in THF and stirred overnight. The reaction was quenched with ACOH (1 mL) and 40 mL pH 7 phosphate buffer. The organic phase was dried (Na2SO4), filtered, and evaporated to yield the title compound 1.1 g.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06583126B2
Source dataset	uspto-grants-2003_06
ORD ID	ord-d520ae0d3de04613a28aa2506186c2af
Source note	uspto-grants-2003_06