Piperidine → HCID 178423279, compound

Participants

Reaction Steps

Using the method described in Example 30 by employing 5-(1-pyrrolidinylvinyl)-2,3-dihydrobenzo[b]furan (freshly prepared before use from 5-acetyl-2,3-dihydrobenzo[b]furan (Avocado Chemical Company), pyrrolidine and TiCl4 (1.20 g, 5.58 mmol), 2-methyl-4,6-dichloro-5-nitropyrimidine (Example 76(b)) (1.20 g, 5.58 mmol), N,N-diisopropylethylamine (1.0 mL, 5.58 mmol), piperidine (0.9 mL, 8.9 mmol), NEt3 (1.1 mL) and SnCl2 (17 ml of a 2 M soln in DMF). In this example the 2 M SnCl2 solution was added to the reaction mixture at 140° C. Heating was then discontinued and the mixture was allowed to cool to room temperature. The mixture was stirred at room temperature for an additional 48 h. The residue was purified by flash chromatography on silica gel with 95:5 CHCl3/MeOH as eluant to give 686 mg (37%) of 5-[2-methyl-4-piperidylpyrrolo[4,5-d]pyrimidin-6-yl]-2,3-dihydrobenzo[b]furan as a beige colored solid. This compound (686 mg, 2.05 mmol) was dissolved in 3:1 EtOAc/MeOH (50 mL) and heated to boiling. To the hot solution was added 1 M ethereal HCl (2.10 mL, 2.10 mmol). The solution was allowed to cool to room temperature. The resulting solid was collected by filtration, washed with EtOAc (2×10 mL), Et2O (3×15 mL) and dried under vacuum at 60° C. to give 591 mg (29%) of the title compound as a beige colored powder. Mp: 170-172° C. 1H HMR (DMSO-d6; 500 MHz): δ 1.69 (br s, 6), 2.56 (s, 3), 3.29 (t, 2, J=8.7), 4.04 (br t, 4, J=5.4), 4.63 (t, 2, J=8.7), 6.76 (s, 1), 6.94 (d, 1, J=8.3), 7.74 (d, 1, J=30 8.3), 7.85 (s, 1), 11.78 (s, 1), 14.21 (s, 1). MS m/z: 335 (M+1 for free base). Anal. Calcd for C2OH22N4O.HCl.1.25H2O: C, 61.01; H, 6.48; N, 14.23; Cl, 8.90. Found: C, 61.17; H, 6.64; N, 14.19; Cl, 8.89.

Provenance & Evidence