4-Piperidinol, 4-(3-(trifluoromethyl)phenyl)-, hydrochloride → HCID 178433078, compound

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Reaction Steps

The title compound was prepared according to the procedure described in Example 173, using 4-[3-(trifluromethyl)phenyl]-4-piperidinol hydrochloride (Acros Organics) (0.6 g, 2.1 mmol) and 2-methyl-4-chloro-6-phenylpyrrolo[3,2-d]pyrimidine (Example 1e) (0.42 g, 1.73 mmol), as a white solid (0.5 g, 59%). 1H NMR (DMSO-d6; 400 MHz): d 1.83 (d, 2, J=13), 2.18 (t, 2, J=11), 2.59 (s, 3), 3.73 (br s, 2), 4.81 (br s, 2), 5.70 (s, 1), 6.93 (s, 1), 7.49-7.62 (m, 5), 7.83 (d, 1, J=7.6), 7.89 (s, 1), 7.97 (d, 2, J=7.6). MS m/z: 453 (M+1). Anal. Calcd for C25H23F3N4O.1.17HCl.0.17H2O: C, 60.25; H, 4.96; N, 11.25; Cl, 8.33. Found: C, 60.25; H, 5.16; N, 10.88; Cl, 8.18.

Provenance & Evidence