9-Fluorenylmethyl chloroformate → (9H-fluoren-9-yl)methyl prop-2-yn-1-ylcarbamate

Participants

Reaction Steps

To a solution of propargylamine (250 μL, 3.645 mmol) in diisopropylethylamine (1.273 mL, 7.290 mmol), was added 9-fluorenylmethyl chloroformate (Fmoc), dissolved in 7 mL dimethylformamide. The mixture was stirred under argon overnight at room temperature. After completion, the solution was reduced in vacuo. An ethyl acetate/water extraction procedure was performed to isolate the product; MS: 278.10 (m/z).

Provenance & Evidence