Water → HCID 21197493, compound

Participants

Reaction Steps

To a solution of (3-trifluoromethylsulfonylamino-2-naphthyloxy)acetic acid tert-butyl ester (1.46 g, 3.60 mmol) in CH2Cl2(37 mL)-anisole(0.1 mL)-water(0.57 mL) at room temperature under nitrogen was added trifluroacetic acid (5.7 mL). After stirring at room temperature for 16 hrs, the mixture was evaporated to dryness and chased with toluene-CH2Cl2 (1:1). The residue was triturated with Et2O to give the title compound (1.17 g, 92%) as a solid. TLC(MeOH-CH2Cl2; 1:9) Rf=0.04.

Provenance & Evidence