反应详情

Dissolve 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine (0.35 g, 1.19 mmol) in pyridine (3 ml). Add methyl chloroformate (0.10 ml, 1.31 mmol, 1.1 equivalents) and stir at room temperature under nitrogen overnight. Dilute with ether, wash with 1N aqueous hydrochloric acid (2×), dry over anhydrous sodium sulfate, filter, and concentrate solution in vacuo. Purify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes to provide the title compound as a white solid (0.15 g, 36%). LC-MS m/z 353.1 (M++1).

1. washwash with 1N aqueous hydrochloric acid (2×)
2. dry with materialdry over anhydrous sodium sulfate
3. filtrationfilter
4. concentrationconcentrate solution in vacuo
5. customPurify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes